Information on this page, including unit offerings, is from the 2019 academic year.
Systems Biology (BIO378)
|Organisational Unit||Biomedical Science|
|Teaching Timetables||Murdoch S2
|Description||Rapid developments in technology have provided the ability to generate large datasets of complex biological systems. The key to using information to create a whole-of-organism picture of cellular processes and to answer biologically-relevant questions lies in integrating information from 'omics data-streams. This unit will consolidate knowledge of microbiology, molecular biology, chemistry and biochemistry to examine in detail the tools that are used to study these systems, including the bioinformatics and functional approaches needed to analyse large data sets.|
|Unit Learning Outcomes||1. Identify the major systems analysis approaches being used to understand complex biological data in biology and medicine.
2. Examine the -omics methodologies being used to generate large data sets of gene, protein and metabolite measurements.
3. Actively explore how these large data sets are manipulated, analysed and visualized to generate biological information (bioinformatics).
4. Understand how top-down (statistical) and bottom-up (mechanistic) approaches are used to interpret complex biology and generate new hypotheses.
5. Explore existing and emerging applications of systems biology in microbiology, medicine, forensics and biology.
6. Develop your skills in generating research questions and applying systems biology.
|Timetabled Learning Activities||Lectures 2 hours per week; workshops 2 hours per week.|
|Unit Learning Experiences||In this unit, you will learn about the fundamental tools available for the study of biological processes at the whole organism level, including genomics, proteomics and metabolomics. This will also include the bioinformatics skills required to mine these datasets and answer biological questions. Through a series of case studies, the application of these technologies will be explored in a range of contexts. Assessment in this unit is based on the completion of workshop assignments and a final exam.. In the workshops, you will work in small groups to explore how the systems biology tools might be applied to particular systems. Training in the handling of actual -omics data will be provided to develop student bioinformatics skills.
|Assessment||Assessment task 1: Workshop assignments Alignment to ULOs: 1, 2, 3, 4, 5, 6 Word length: Workshop specific Weighting: 50%; marking time: 120 minutes Due date: Continuous
Workshop specific Assessment task 2: Final exam Alignment to ULOs: 1, 2, 3, 4, 5 Word length: Exam specific Weighting: 50%; marking time: 120 minutes Due date: End
|Prerequisites||BIO270 Biochemistry I or BIO247 Biochemistry or BMS261 Human and Comparative Biochemistry or VET272 Comparative Mammalian Biochemistry; BIO282 Molecular Biology or BIO316 Molecular Genetics.|
|Previously||2015: 'Systems Biology and Bioinformatics'|
|Appears in these Courses/Majors:
see individual structures for context
|Internet Access Requirements||Murdoch units normally include an online component comprising materials, discussions, lecture recordings and assessment activities. All students, regardless of their location or mode of study, need to have access to and be able to use computing devices with browsing capability and a connection to the Internet via Broadband (Cable, ADSL or Mobile) or Wireless. The Internet connection should be readily available and allow large amounts of data to be streamed or downloaded (approximately 100MB per lecture recording). Students also need to be able to enter into online discussions and submit assignments online.|