Information on this page, including unit offerings, is from the 2020 academic year.
Research design in systems medicine (BIO510)
|Organisational Unit||Medical, Molecular and Forensic Sciences|
|Description||This unit is designed to deliver the knowledge and proficiencies necessary for students to develop a research project proposal with a current literature review that guide the design and implementation of a thesis in Systems Medicine. Students will also formulate a research question extracted from the literature review and in planning their own research protocol (including relevant content, milestones, deliverables and timelines) with their project supervisor(including members of staff at the ANPC and Murdoch University).|
|Unit Learning Outcomes||On successful completion of the unit students should be able to:
ULO1: Use the literature to understand a field of knowledge, identify gaps in knowledge and develop a research program to address the gaps in their chosen field of study.
ULO2: Demonstrate a coherent understanding of the necessary components of a research proposal, including development of a plausible and testable hypothesis with research questions
ULO3: Develop the necessary protocols to test a hypothesis and undertake research within a defined area of study
ULO4: Justify their scientific decision-making with respect to research design and be able to justify appropriate analytical techniques application
UL05: Design and plan a substantial piece of research in systems medicine
ULO6: Develop communication (technical writing and oral presentation) skills in disseminating research to audiences of different levels
ULO7: Develop practical skills in sample preparation and separation science
ULO8: Develop proficiency in biomarker identification by applying practical solutions using chromatographic and other analytical techniques.
UL09: Recognise limitations in analytical design, implementation and biological interpretation
|Timetabled Learning Activities||2 hr seminar weekly for 10 weeks, 12 hours workshops, 100 hours laboratory work|
|Unit Learning Experiences||Students will be expected to devote 30 hours per week to this unit. This includes reading literature and development of practical skills in chromatography, NMR spectroscopy, mass spectrometry and sequencing techniques. These activities will include structured and project associated laboratory time in addition to independent and group literature reviews, and engaging in small group discussions. The approach to learning in this unit incorporates a mixture of structured timetabled learning (100 hours of laboratory time, 12 hours of workshops), semi-structured timetabled learing (20 hours seminars), semi-structured non-timetabled learning (face-to-face meeting with project supervisor specific to their chosen area of project) and a sizeable focus on self-directed learning. These differing approaches will allow students to achieve the unit learning outcomes and to develop deep knowledge of successful research processes.
Students will also gain extensive practical skills through structure-based and project-associated competency aboratory sessions. These laboratory sessions will teach students the skills of sample preparation, sample analysis by different spectroscopic methods, basic sequencing preparation and analysis techniques such as Q-PCR, bioinformatics including pre-processing and data analysis of spectroscopic data as well as separation science, pharmacometabonomics and structural identification of unknown compounds or 'biomarkers' in biological specimens such as urine and serum. Discussion on recently published manuscripts in the above-mentioned analytical areas will form the focus of the weekly seminar sessions and students will learn to critically evaluate aspects of experimental design, sample handling, analytical measurement, bioinformatic analysis and biological interpretation.
|Other Learning Experiences||Students will actively participate as researchers in omics based research projects currently running within Murdoch University.|
|Assessment||Students will be assessed via a: Research Proposal (40%), Laboratory Skills Assessment (40%) and an oral research proposal presentation (20%).|
|Prerequisites||Enrolment in Master of Systems Medicine (Research), or completion of Graduate Certificate in Systems Medicine with minimum scores of 65%.|
|Notes||This unit builds on the Advanced Research Methods for Scientists (VLS683) unit and offer hands on learning experience.|
|Appears in these Courses/Majors:
see individual structures for context
|Internet Access Requirements||Murdoch units normally include an online component comprising materials, discussions, lecture recordings and assessment activities. All students, regardless of their location or mode of study, need to have access to and be able to use computing devices with browsing capability and a connection to the Internet via Broadband (Cable, ADSL or Mobile) or Wireless. The Internet connection should be readily available and allow large amounts of data to be streamed or downloaded (approximately 100MB per lecture recording). Students also need to be able to enter into online discussions and submit assignments online.|
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